{"id":25,"date":"2026-07-21T16:59:20","date_gmt":"2026-07-21T16:59:20","guid":{"rendered":"https:\/\/fullgen.com\/wordpress\/?page_id=25"},"modified":"2026-07-22T23:33:02","modified_gmt":"2026-07-22T23:33:02","slug":"research","status":"publish","type":"page","link":"https:\/\/fullgen.com\/?page_id=25","title":{"rendered":"Research"},"content":{"rendered":"\t\t
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Technology Platforms & Research Capabilities<\/em><\/h2>\n\t\t\n<\/div>\n
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AUTOMATED CELL CULTURE PLATFORMS WITH LIVE CELL IMAGING <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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We develop custom-fabricated PDMS lab-on-chip devices coupled with automated imaging systems monitoring cell behavior in real time over extended periods. Our platforms integrate precise fluidic control with deep learning\u2013based image analysis pipelines, enabling quantitative, long-term studies of proliferation, migration, and drug response \u2014 with minimal operator intervention. A key application is the automated culture and imaging of T-lymphocytes in lab-on-chip devices, where deep-learning algorithms quantify proliferation kinetics over days without manual intervention. These systems are developed in collaboration with international partners and leading research institutions in Germany and the United States. Our live cell imaging system has reached TRL 3: a locally designed and assembled precision micro-positioner integrates a brightfield microscope with an automated image acquisition system. It operates inside a standard cell incubator under controlled temperature and atmosphere, demonstrating the technical feasibility and reliability of the platform in a relevant laboratory environment.<\/p>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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Mechanical stage: <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Automated XYZ micro-positioner (CAD model). <\/strong>Three-axis precision stage integrating a brightfield microscope, stepper motors, linear guides, and an adaptable top platform for Lab-on-a-Chip devices, enabling programmable position control and image acquisition during biological experiments.<\/p>\n\t\t

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Front view.<\/strong> XYZ stage with stepper motors, connected to a computer for programmable motion control, image acquisition, and syringe-pump perfusion.<\/p>\n\t\t

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Side view.<\/strong> Detail of the mechanical assembly showing precision linear guides and stepper motor configuration.<\/p>\n\t\t\n<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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Incubator <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Provides a controlled, protected environment to promote cell growth. <\/p>\n\t\t\t\t\t\"\"\/\t\t\t\t\t

System inside a standard incubator. <\/strong>The micro-positioner operates within a conventional cell incubator, enabling biological experiments under controlled temperature and atmospheric conditions.<\/p>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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Custom Software platform <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Custom software platform. <\/strong>Purpose-built interface for configuring and controlling the micro-positioner: users define multiple XYZ positions, time-lapse intervals, and automated image capture across the microfluidic device \u2014 enabling unattended longitudinal experiments.<\/p>\n\t\t\n<\/div>\n

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Yeast cells in a microfluidic device.<\/strong> Brightfield image acquired with the integrated microscope system. Cells grow inside the chip mounted on the micro-positioner, inside the incubator, demonstrating real-time monitoring capability under controlled culture conditions.<\/p>\n\t\t\n<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Technology Platforms & Research Capabilities AUTOMATED CELL CULTURE PLATFORMS WITH LIVE CELL IMAGING We develop custom-fabricated PDMS lab-on-chip devices coupled with automated imaging systems monitoring cell behavior in real time over extended periods. Our platforms integrate precise fluidic control with deep learning\u2013based image analysis pipelines, enabling quantitative, long-term studies of proliferation, migration, and drug response … Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-25","page","type-page","status-publish"],"_links":{"self":[{"href":"https:\/\/fullgen.com\/index.php?rest_route=\/wp\/v2\/pages\/25","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fullgen.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/fullgen.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/fullgen.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fullgen.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25"}],"version-history":[{"count":16,"href":"https:\/\/fullgen.com\/index.php?rest_route=\/wp\/v2\/pages\/25\/revisions"}],"predecessor-version":[{"id":200,"href":"https:\/\/fullgen.com\/index.php?rest_route=\/wp\/v2\/pages\/25\/revisions\/200"}],"wp:attachment":[{"href":"https:\/\/fullgen.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}